Neurofibromatosis 2 (NF2) is an autosomal disorder characterized by the development of multiple nervous system tumors such as vestibular schwannomas. The purpose of the study is to define the growth rate and clinical course of vestibular schwannomas in NF2- affected individuals. We will develop an international consortium of clinical centers with expertise in NF2, standardize the radiographic analysis of the vestibular schwannomas, assess the patients' audiological functioning, and analyze molecular, pathological, and clinical features of the disease over the course of 3 years. We have enrolled 97% of the target goal of 100 study participants. The difficulty enrolling patients has stemmed from a protracted informed consent approval process and one co-Pi leaving a core site. Baseline audiological data and baseline MRI have been collected for 64% and 71% of enrolled subjects, respectively. We have made good progress toward completion of the study's goals and anticipate few problems with the collection of one-year follow-up data.